Well I am by no means any type of expert but there are some things I can think of that may need to be address. What type of coolant are you running? Exhaust? Engine, and so fourth.
If you have basic cooling using a clutch style fan then you have to be careful about the fan distance. To close and you will hydro wind so to speak or even hit the coils.
Than it depends on what engine your running. You have to watch your oil pan drop. You have a whole lot of things going on in the front there like steering linkage and axle movements during wheeling. If you have a big drop down oil pan it may hit. Also think about if you ever need to get to it for maintenance or repairs. I've heard some folks needed to losing up the springs to drop the pan.
Then you have to watch if your exhaust will interfere with anything if you move it up. If your running a V8 this would be more crictical then a straight motor.
Another thing to think about is center of gravity. If you never wheel then I wouldn't worry about that to much unless you like to drift around sharp corners. Remember jeeps are off balance as it is and we start lifting them and adding bigger tires. Then you move more weight forward. May only be an inch but it really changes the center of gravity.
If you're running an electric fan set up, have a straight 4 or 6 motor with only one exhaust set-up and don't do major hill style wheeling I would say it's not really a big deal. Move the motor mounts, re-pipe your exhaust, and get new drive shafts. Also need to redo the fuel lines, electrical wires such as engine to body harness unless you have enough slack, heater hoses if your running one, and gas pedal linkage...